In addition, the test for trend did not suggest a linear effect of the variant alleles across the genotypes on triptan non-response for either polymorphism.
We also investigated for a potential linear effect of the variant alleles across the genotypes on triptan non-response using a test for trend.
The effect of the variant on AE3 function has not been assessed.
This is highly indicative of how low the effect of the variant is on the genetics of ET in the French-Canadian population.
Separate ANOVAs performed in individual parrot species (Bonferoni corrected Ps<0.05) revealed no effect of gender, but confirmed the effect of the variant in 13 species.
The main effect of the variant genotypes on the risk of lung cancer was estimated by odds ratios and their 95% confidence intervals using unconditional logistic regression analysis.
Hence, both the lower antagonistic and the increased agonistic potencies are compatible with an elevated MC4R function, which could explain the weight-reducing effect of the variant.
There were no consistent differences in allele frequency between men and women in either controls or patients; therefore we exclude a gender specific effect of the variant.
Co-expression of the FL isoform with the truncated isoform in COS-7 cells resulted in a reduced uptake of substrates, indicating a dominant negative effect of the variant.
In GWAS, researchers assume that the genetic variant explains variance in the latent trait, and that the effect of the variant on individual items or symptoms is mediated by the latent trait (Figure 1a).
Since the INSIG2 rs7566605 C-allele has been proposed to exert a larger effect in individuals already predisposed to obesity, we investigated the effect of the variant in the obese subgroup of the combined study sample (n = 3,878), with a mean BMI of 32.8 kg/m2, however, no genotype effect was found (data not shown).
