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One of the first findings that, although indirectly, suggested the role of TRP channels in cluster headache and migraine was represented by the protective effect of the topical, desensitizing application of capsaicin to the patient nasal mucosa [79, 80].
In this study, the effect of the topical anesthetic Oraqix® versus the placebo Vaseline® on discomfort or pain from the very beginning of the placement of the orthodontic elastomeric separators was analyzed.
The aim of this study is to investigate dose-dependent effect of the topical application of methotrexate (MTX) in rats on the normal nasal mucosa, liver tissue, liver enzymes, and hemoglobin levels.
Thus, both the functional and quantitative control of MCs might explain the observed anti-allergic effect of the topical treatment with adelmidrol.
This is also true in clinical settings, as others reported the acupuncture-like effect of the topical application of capsaicin on acupoints [ 56, 57].
In the last several years, various in vitro and in vivo experimental and clinical studies have investigated the bactericidal effect of the topical application of ozone in different situations, including the management of infected wounds [ 6- 8].
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The effects of the topical control cream have been described by several other investigators.
We evaluated the effects of the topical application of a lotion containing GSSG to the face for 10 weeks.
This suggested that the systemic toxicity and side effects of the topical formulation of tetrandrine would be neglected.
35 Therefore, currently available data do not suggest that 'unknown risks' of topical tacrolimus need be any more concerning than the known side-effects of the topical steroids.
The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring.
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