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However, direct evidence of microglial proliferation (incorporation of 5-bromo-2-deoxyuridine in Iba1+ cells) was only recently reported, suggesting a direct effect of the plaque microenvironment over the regulation of microglial proliferation [ 62].
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The findings of the present study like that of the Brown's review, however, contradicted the conclusion of a review of dental health education programs by Kay and Locker [ 23] that school-based dental health education programs, no matter whether led by dentists, teachers or peers, had no effect on the plaque level of the study subjects.
But Lp-PLA2 may participate in coronary heart disease by modulating inflammation independent of effects on the plaque itself.
The aim of this work was to investigate the dose-modifying effects of the plaque and the seed fixating silicone rubber glue.
Similarly, adiponectin virtually completely ablated the effect of the cold-induced plaque instability.
For the effect of carotid plaque, detectable differences in the functional assessments of endothelial function ranged from 33%to50%0%, at 80% power with alpha of 0.006.
Therefore, the negative effect of plaque on the marginal bone levels for this study can be considered negligible.
Moreover, Ang-2 depletion had no effect on the stability of the plaque phenotype as microvessel density, macrophage and collagen content and the necrotic cores remained unchanged (Table 1).
The possible function of these subsets in plaque stability can, in part, be gleaned from understanding the effect of the stimulating cytokines on plaque development in murine models.
Steven Nissen, the chairman of cardiology at the Cleveland Clinic and head of the American College of Cardiology, will present one key study that will use ultrasound probes to measure the effect of torcetrapib on plaque in the coronary arteries at the ACC meeting in New Orleans next March.
Even if a clear antimicrobial effect could be found, this finding demonstrates a prolonged effect of the xylitol on different plaque-related variables.
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