Sentence examples for effect of the mutant from inspiring English sources
A comparison between the observed and the expected genotypic frequencies showed that they were significantly different for the ESN group, suggesting a protective, yet indirect effect of the mutant genotype.
"I really do think this represents a step forward," he says, adding that the findings could eventually lead to therapies that use a molecule to overcome the effect of the mutant gene.
The apoptotic-like effect of the mutant 373 was identical to that of MF37 but its necrotic-like activity was significantly reduced.
As the transferrin receptor is located correctly at the plasma membrane in TS-mutant cells at 42°C, impaired endocytosis is a direct consequence of the temperature-sensitive effect of the mutant clathrin.
Therefore we define a function β(bxy−bxym) describing the effect of the mutant strategy bxym on the resident strategy bxy which is a decreasing function of bxy−bxym.
The reduction in the level of murine wildtype p53 protein may be associated with overexpression of p53 ubiquitin protein ligase Pirh2 and the "dominant-negative" effect of the mutant p53.
The enhancing effect of the mutants was clearly IKKβ-dependent, as tested again in IKKβ-deficient 3T3 cells.
This must be an effect of the mutants because ectopic expression in wild-type flies allows translation and ectopic bristle formation.
The conclusion in the text is that there is no effect of the mutants on activity, but an effect on telomere length.
At 37°C the negative effect of the mutants on lysis rate might be explained by lower transcript levels for the lysis protein.
