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However, in the IWA6988 × IWA167 interaction, the presence of the susceptible alleles from one of these two loci was associated with a reduction or elimination of the effect of the interacting locus.
The growth-promoting effect of the interacting loci was highly dependent on the genotype at Growth9 as HWS homozygosity at this locus was required for the other interacting loci to have a significant effect on growth.
The effect of the interacting flexible structure is included via a coupling computation.
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The SEN method only considers purely epistatic interactions, i.e., it measures the effect of the interaction outside of the individual main effects of the interacting SNPs.
Importantly, changing the mitochondrial background alters the effects of the interacting nuclear genes without changing the nuclear gene sequence.
Nevertheless, when effect size is measured simply by comparing overall liability marker scores for those with the risk and nonrisk versions of the gene, the effect sizes of the interacting genes were small.
We consider two extensions of the simple model: a general model with an extra parameter that models deviation from the simple model at the heterozygote and an interaction model with an extra parameter that models the joint multiplicative effect of the two interacting SNPs.
Subsequently, results of a comprehensive investigation on the effect of some of the interacting parameters and conditions with the skew angle, namely, ground motion intensity, soil type, abutment support conditions with nonlinear soil interaction and shear keys, bridge aspect ratio, and foundation base conditions, are reported.
The authors exploit a parametric model in which crowd motion is represented as the effect of forces interacting among the agents.
The analyses will be based on a mixed-model-repeated-measurement (MMRM) analyses of change from baseline with the effect of the exposure variable interacting with the time point (month), using the observed cases and an unstructured variance-covariance matrix.
Most of the symptoms and signs of scorpion envenomation have been attributed to the effects of the venom interacting with sodium channels and of neurotransmitters released from autonomic nerve endings [9, 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com