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Table 1 Inhibition effect of the compounds 4, 5a 5q against Xoo and Rs Compd.
The anxiolytic effect of the compounds was investigated employing the Elevated plus Maze (EPM) task.
Differential scanning calorimetry was applied for measuring the effect of the compounds on the thermotropic behaviour of the vesicles.
Further the cytotoxic effect of the compounds examined on cancerous cell lines showed that the complex exhibited substantial anticancer activity.
The combined action/synergistic effect of the compounds in TPD displayed remarkable improvement in corrosion inhibition and inhibition efficiency [26, 27].
Moreover, the apoptosis inducing effect of the compounds was studied using Hoechst staining, Rhodamine 123 staining (MMP), carboxy-DCFDA staining (ROS), Annexin V-FITC assay.
The inhibitory effect of the compounds was investigated against hen egg white lysozyme (HEWL) fibrillation using AFM (atomic force microscope), ThT (thioflavin T) and MTT assay.
Changing the resorcinol substitute to position 3,5- or placing it on ring A significantly diminished the inhibitory effect of the compounds.
The cytotoxic effect of the compounds 1-5 againstwowo tumor cell lines, PC-3 (prostate cancer cell) and Hela (cervical cancer cell), was evaluated (Table 3) using the MTT assay.
The quenching spectra for 1A and 1B with HSA and BSA are shown in Additional file 1: Figure S1. Figure 4 Effect of the compounds on the intrinsic fluorescence of serum albumins.
The 96-well microplate assay is based on the effect of the compounds on growth of asynchronous cultures of P. falciparum, as determined by the fluorometric SYBR green assay [21].
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