Sentence examples for effect of the checkpoint from inspiring English sources

Second, the effect of the checkpoint proteins which are not directly involved in the sequestration/inhibition (Bub1 and Mad1) can only be captured through the kinetochore network.

Secondly, PLK1 activation, by mediating a phosphorylation dependent degradation of Claspin, leads to the inactivation of CHK1 and hence alleviates the opposing effect of the checkpoint protein to the cell cycle (Mamely et al, 2006; Peschiaroli et al, 2006).

This report describes the effect of the Checkpoints Program on driving limits and outcomes.

Thus, it was concluded that the effect of the clock on checkpoint and apoptosis could be reliably compared only in the same cell strain in which the particular clock protein is downregulated by siRNA.

The evidence that PD-L1 expression is a potential negative prognostic factor in several cancers further supports the hypothesis that the observed improvement in TTP was related to an indirect effect of the therapy on checkpoint expression (Zou and Chen, 2008).

The same effect was also observed at 10 μM nocodazole or 15 μM colchicine, ruling out an off-target effect of the spindle poison on the checkpoint, or an effect of residual microtubules on checkpoint satisfaction (Supplementary Figure S4).

Addition of hesperadin at 100 nM caused a dramatic effect on the duration of the checkpoint response, with cells being completely unable to arrest in mitosis in high nocodazole.

In fact, exploiting extreme CIN as a positive anticancer approach has been proposed by inhibiting Mps1 (mitotic checkpoint kinase) or the synergistic effect of mitotic checkpoint inhibition coupled to sublethal doses of paclitaxel.

Although disabling point mutations in TP53 are only found in 10%% of melanomas, inactivation of the protein is found in approximately 90%% of the tumours (reviewed in [ 42]), suggesting that the effect of checkpoint inhibition in melanoma is not strictly dependent on the p53 mutation status.

To investigate this further, the effect of inactivating the mitotic checkpoint through deletion of MAD2 was investigated.

Here we describe the cellular effects of the pharmacological inhibition of the checkpoint kinase Chk1 by the novel inhibitor V158411 in triple-negative breast cancer and ovarian cancer.