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The effect of the causative locus on the probability of getting the disease can be approximately estimated though the odds ratio associated with the SNP.
This could be due to the elimination in the association tests of the effect of the causative mutation in PPARD involved in the other major QTL for ear size on SSC7.
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The calculation process is based on the evaluation of the probability of exceedance of specified acceleration levels without consideration of the damaging effects of the causative earthquakes.
The true BV of an individual was obtained as the sum of all allele substitution effects of the causative loci, accounting for the individuals' genotype at these loci.
There will also be an underestimation of the genetic effect of the known loci since they are represented by their surrogate linked SNPs, and the true effects of the causative alleles themselves could be greater.
However, altered expression of many genes in Li 1 – Li 2 transcriptomes can be result of chain-reactions to adverse effects of the causative mutation, and is not necessary directly related to fiber elongation process.
First, an important factor to consider when looking at migraine is the effect size of the causative variants.
> -wrap-foot> The power estimates for the non-clustered scenario show that our constructed DBM had a better performance than the collapsing approach (CMC), the two methods based on weighting schemes (Price, MB) and the SKAT and C-Alpha test, when the effect direction of the causative rare variants is the same.
Though meanwhile it introduces a greater number of causative variants as well, the phenotypic effect of these causative variants, that is, gene heritability, remains unchanged.
Significant markers could potentially represent causative mutations within previously identified genes, functional RNAs or regulatory regions, or more likely are not causative by themselves but in sufficient linkage disequilibrium (LD) to pick up the effect of the nearby causative factor.
The LHEF rating scheme is a numerical system, which describes the slope instability in terms of cumulative effect of the major causative factors of the slope instability [11].
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