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Haplotype associations for the two loci were also studied in order to determine any possible synergistic effect of the associated alleles.
The effect of the associated or tagged variants on the respective genes and their role as eQTL on other genes could not be ruled out.
To sum up, our elastream facilitates the use of cloud computing resources for these tasks and its streaming option is of significant advantage to mitigate the effect of the associated data transfer latency.
In such combinations, uninfective pathogen races are not directly exposed to the selective impact of the APR gene due to the overriding pleiotropic effect of the associated R gene(s).
In two of the AD loci, we had the opportunity to evaluate the possibility that DNA methylation mediates the effect of the associated variant since both the CR1 index SNP and the APOE e4 haplotype as well as some of the CpGs in each locus are associated with NP burden and AD, which is a prerequisite to formally test mediation.
The function of CDKAL1 is not currently known, although the association of this gene to T2D may be related to an effect of the associated SNP on insulin response (Steinthorsdottir et al. 2007).
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These previous works highlighted the antiangiogenic properties or antiproliferative effects of the associated compounds.
In addition, we separately analyzed a subset of patients who received specific combination therapies by GWASs and applied the weighted genetic risk scoring (wGRS) system to investigate the cumulative effects of the associated SNPs.
The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians.
The purpose of the procedural control was to test for the effect of the disturbance associated with bait-pumping.
27 28 Imputation was performed to minimise the effect of the bias associated with selectively ignoring these patients.
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