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Fortunately, in the absence of injury, turnover of endothelial cells in situ is exceedingly low, and the effect of the administered and slowly released siRNA should last more than 10 days.
The effect of the administered fluid bolus was reassessed in every 15 min.
This because the fetal hyperinsulinism consequent to the maternal hyperglycemic peak could block the beneficial effect of the administered betamethasone on fetal pulmonary maturation.
This is a noteworthy result that could be due to a sample size effect or, alternatively, due to lack of an effect of the administered preventive measure on mortality.
However, the two different time points were chosen in accordance with the clinical expectation of maximal effect of the administered drug, which would theoretically increase the chance to observe a change, not only for GCs, but also for MTX.
However, the robust activation of innate immune parameters was not associated with a decrease in HBV titer within the first 2 weeks of therapy, suggesting that the modulation of innate immune responses was a direct effect of the administered IFN-α and not secondary to its antiviral effect.
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There do not appear to be any particular adverse effects of the administered enzyme secondary to antibody production, although there were IgE-mediated reactions in these mice receiving human GCases leading to death.
No dropout was related to side-effects of the administered collagen peptide supplement or placebo.
For the clinical application of the novel therapeutic approach, an evaluation of adverse effects of the administered agents is crucial.
In chronic metal-induced disease, where life-long chelation may be necessary, possible toxicity or side effects of the administered chelator may be limiting.
Finally, the protective effect of the extracellularly administered BH4-domain proteins is not limited to I/R.
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