Sentence examples for effect of the abrogation from inspiring English sources

The above data prompted us to investigate the effect of the abrogation of CCR9 on murine CIA.

The role of p53-family members in the transcriptional regulation of NIS expression was further confirmed by the strong effect of the abrogation of p53, p63 and p73 expression by specific siRNAs (Supplementary Figure S3) on NIS promoter activity.

In this study, we examined the stimulatory effects of CCL25 on FLS and monocytes and effects of the abrogation of CCR9 on a murine model of RA.

This work elegantly and systematically describes the effect of abrogation of the gamma secretase component Aph1B in synaptic transmission, plasticity, and dendritic spine formation, and provides convincing data pointing towards the neuregulin 1 intracellular domain as a downstream regulator of these events.

To assess the effect of Trf1 abrogation in the context of lung cancer induced by expression of the K-Ras G12V oncogene, we crossed K-Ras+ /LSLG12Vgeo mice (designated from now on as K-Ras+ /G12V ) (Guerra et al, 2003) to a strain carrying a floxable allele of Trf1 (Trf1 lox/lox ) either wild-type or deficient for p53 (p53−/−) (Martinez et al, 2009) (Fig. 1A).

The first effect is the abrogation of growth inhibition mediated by RA through RARα, and the second effect is a non-RARα-mediated stimulation of cell growth by RA itself.

The major effect of wortmannin was the abrogation of stabilin-1/acLDL trafficking into the late endocytic pathway.

Next, we addressed the effect of Trf1 abrogation in immortalization of MEFs.

Using one such cell line, K1, we have tested the effect of experimental abrogation of p53 function by generating matched sub-clones stably expressing either a neo control gene, a dominant-negative mutant p53 (143ala) or human papilloma virus protein HPV16 E6.

We then examined the effect of abrogation of E-cadherin function on the activity of the EGFR/ERK and PI3-K/AKT pathways.

The pivotal aim of this study was to determine whether lupeol exerts its anticancer effects through the abrogation of the STAT3 signalling pathway in HCC cells.