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Finally, in order to investigate the size of the cofactor and substrate pockets, we introduced variations to parts A and C, exploring the effect of terminating the molecule with a single ring on both ends (product 36), with a bicycle (derivatives 33 and 37) or a tricyclic system (Scheme 5).
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The cost of terminating the interest-rate swaps was exorbitant.
At right, the plot illustrates the effect of terminating trajectories at a distance of 20 σ, rather than 4.5 σ, from the origin.
"They're saying, 'We can't apply the rules that govern the effect of terminating J-51 benefits because J-51 benefits are terminated,' " he said.
Although G. destructans is not vasculotropic - that is, it does not directly invade blood vessels - effacement of the vasculature caused by this fungus could have the same effect of terminating blood flow to a region.
As a result, terminating the activity of any other enzyme in that pathway should have the same effect.
The effect of the terminating group was considered by comparing the dimethyl ethers with hydroxy-terminated poly ethylene oxide) at comparable chain lengths.
A key player in 5-HT signaling is the 5-HT transporter (5-HTT), terminating the extracellular effects of 5-HT by sodium-dependent intracellular re-uptake [19].
Ecto-ATPases are membrane bound enzymes which dephosphorylate ATP, thereby terminating the stimulatory effects of ATP on P2-receptors.
A limiting effect of the terminating bonds and their contamination by water has been examined in relation with optoelectronical and mechanical properties of the films.
In order to study the effect of terminal groups on the transfection efficiency, each polymer was terminated with 4-aminobutanol (ABOL) or with 2-aminoethanol (ETA).
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