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Often, the activity of the extracts may be the result of an synergistic effect of several compounds.
Tocotrienols can enhance the effect of several compounds including cox-2 inhibitor celecoxib, tyrosine kinase inhibitor gefitinib, and statins such as Simvastatin [ 80– 82].
The objective of these experiments was to study the toxic and/or carcinogenic effect of several compounds on the respiratory tract mucosa.
In addition, biological evaluation of these compounds as pilicides and curlicides showed a great biological effect of several compounds, with some being both potent inhibitors of pili- and curli-dependent biofilm formation and having fluorescent properties.
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The effects of several compounds on chitobiosidase activity were then evaluated (Table 2).
Embryotoxic effects of several compounds (busulfan, hydroxyurea, indomethacin, caffeine, penicillin and saccharin) were tested using a cell proliferation assay.
Our laboratory has been investigating the effects of several compounds on inducing the expression of γ-globin genes and the increase of fetal hemoglobin (HbF) synthesis [ 24– 28].
The topics addressed by the mock submissions were a) microarray data quality using a data set generated for a single compound, b) assessment in a single tissue of the effects of several compounds in a pharmacological class, and c) use of a proprietary database to help classify a compound of unknown toxicity.
These evidences suggest that genes related to differentiation of the mammary gland can be very sensitive to the effects of several compounds that may interfere with hormonal action, suggesting that, even if the effects are not strong enough to modify mammary histoarchitecture, they may change the molecular milieu of the gland.
This paper gives a review of research work in the synthesis of higher alcohols over catalysts based on Cu/ZnO/Al2O3, emphasizing three main topics: (i) the effect on selectivity of the addition of several compounds to this catalyst, (ii) the effect on selectivity of the reaction conditions used, and (iii) the reaction network leading to the different products found.
These doubts are based on the clinical phase III failure of several compounds that had beneficial effects in the SOD-1 (G93A) Tg line [12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com