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In all, these results confirm that running promotes neurogenesis in the dentate gyrus and show that most of the beneficial effect of running on neurogenesis is abolished by inhibition of the PI3K-Akt signaling pathway.
Though previous studies have reported a stimulating effect of running on proliferation under comparable conditions [34], our data are in line with a recent study reporting that proliferation is only increased at the onset of wheel running and returns to baseline levels after 21 days of running [35].
Our results suggest a marked intensity-specific effect of running on the immunolocalisation and gene expression of lubricin in cartilage.
In the current study, a marked intensity-specific effect of running on the immunolocalisation and gene expression of lubricin in cartilage is demonstrated.
There is a marked intensity-specific effect of running on the immunolocalisation and gene expression of lubricin in cartilage, which is inversely correlated with Mankin score.
Silencing the transmission of VIP neurons thus abolished the effect of running on adult plasticity in this mouse model of amblyopia by reducing the potentiation of deprived-eye responses during recovery.
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On at least one occasion, he ran connected to electrodes to study the effects of running on the body.
As demonstrated, irradiation of the hippocampus was sufficient to abolish the effects of running on neurogenesis and anxiety.
However, there are no investigations about the effects of running on leg muscle morphology in older subjects.
Beside the positive effects of running on health and fitness, the risk of a running related injury has to be considered.
After the 3 wk period in cages with running wheels, the rats spent ≥6 wk in normal cage conditions before further measures to avoid the possible effects of running on the basal level analyses.
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