Sentence examples for effect of prpc on from inspiring English sources

The positive effect of PrPC on ferritin iron content is enhanced by stimulating PrPC endocytosis, and reversed by cross-linking PrPC on the plasma membrane.

Although we could not detect measurable ferroxidase activity of recombinant PrP, such a function of cell associated PrPC would explain the facilitative effect of PrPC on iron incorporation into ferritin.

The positive effect of PrPC on cellular iron is mainly due to enhanced uptake since the amount released into the culture medium is not altered in any of the cell lines tested.

Thus, we investigated whether the effect of PrPc on T cell proliferation was predominantly mediated through its effects on T cells, or antigen-presenting cells or both.

Our earlier results on the effects of PrPc on antigen-specific T cell activation, proliferation and differentiation suggested that PrPc may serve as an immunomodulatory molecule and specifically that the absence of PrPc amplified TCR signalling.

Before analyzing effects of PrPc on both neurogenesis and underlying mechanisms, we first assessed whether or not PrPc induces sustained reduction of motor coordination impairment and histological brain injury.

To elucidate effects of PrPc on intracerebral NPC homing, we intravenously infused GFP+ NPCs in ischemic WT, PrP−/− and PrP+/+ mice, showing that brain accumulation of GFP+ NPCs was greatly reduced in PrP−/− mice, but increased in PrP+/+ animals.

Based purely on the knockout results, however, it remained unclear whether the effects of PrPc on CNS autoimmunity were due to alterations in the susceptibility of the CNS to inflammation (i.e. neuronal survival) or due to alterations of the inflammatory response.

In light of PrP−/− mice exhibiting reduced PACAP-38 expression, which is critically involved in NPC migration and trafficking, we finally evaluated the effect of PrPc expression on the intracerebral homing of systemically transplanted GFP+ NPCs, furthermore examining effects of NPC delivery on ischemic brain injury and neurological recovery.

At this point, we are investigating the differential effect of PrPc silencing and overexpression on different cell types.

A similar increase in ferritin iron is observed when M17 cells expressing endogenous levels of PrP are exposed to 3F4 (Fig. S4 lanes 1 and 2), ruling out the effect of over-expression of PrPC on these observations.