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Further investigation showed that the inhibitory effect of MH on the proinflammatory cytokines was associated with the downregulation of NF-κB.
The purpose of this study was to determine the effect of MH on FRC in cardiac surgical patients.
The main purpose of this study was to determine the effect of MH on post-operative FRC of cardiac surgical patients.
In accordance, the incidence of signs of atelectasis on post-operative chest radiographs is significant lower in patients who receive MH. Future studies are needed to determine the effect of MH on important clinical endpoints, including duration of tracheal intubation, post-operative pulmonary complications and duration of hospitalization.
Notably, although no effect of MH on arterial oxygenation was found in a study of patients with acute lung injury [ 20], another study found MH to improve arterial oxygenation in patients with indirect acute lung injury but not in patients with direct acute lung injury [ 7, 33].
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Our study is the first randomized controlled trial assessing the effects of MH on FRC in patients after cardiac surgery.
Next, we demonstrated the effect of MH nanoparticles on the corneal surface.
Therefore, appropriately powered, well-designed, randomized controlled trials evaluating the effect of MH should be conducted.
Side effects of MH seemed relatively infrequent.
We, and others, have studied possible adverse effects of MH [ 19, 35, 36].
We reviewed studies of diverse intensive care unit populations investigating the potential beneficial effects and side effects of MH.
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