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We could not detect any effect of LP on IL-6 or IL-10 (Fig. 5).
However, the anti-MIMP deprived the effect of LP on the reduction of EPEC adhesion (P < 0.05, Figure 1D).
Anti-MIMP antibody also inhibited the effect of LP on EPEC-induced decrease in TER (P > 0.05, Figure 2A).
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Phytoestrogens are often potent antioxidants and anti-inflammatory agents which may explain the effects of LP on women's health.
The present study was therefore arranged to investigate the protective effects of LP on lungs against CCl4-induced oxidative damage in rats.
This could indicate an effect of Lp 299v on the mucosal barrier, or on the immune system, as shown in the studies on Lactobacillus plantarum 299 on pancreatitis transplant patients and liver transplant patients [ 23, 24].
To analyze the eventual effect of Lp(a) on diabetes, a multivariate logistic analysis was carried out.
To investigate a putative causal effect of Lp(a) on PAD, IV regression analysis was performed using LMW apo(a) phenotypes and the SNP rs10455872 as the IVs on log-Lp(a).
Additionally, to investigate the effect of Lp(a) on insulin resistance, a parametric model was developed to describe the relationship between age and HOMA-IR values in subjects with levels of Lp(a) ≤46 or >46 mg/dl.
A multivariate logistic regression model with L2-regularization was used to assess the independent effect of Lp(a) on diabetes and its interactions with variables traditionally linked to the disease.
Moreover, since apo(a) phenotypes and the SNP rs10455872 within the LPA gene were determined for each of the investigated cohorts, it was possible to apply a Mendelian Randomization approach to evaluate a putative causal effect of Lp(a) on PAD which is otherwise hardly possible using conventional epidemiological methods.
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