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Here, we describe a multi-SNP association method that estimates the effect of loci harboring multiple association signals by using GWAS summary statistics.
Haplotype analysis may identify susceptibility loci that are not captured by single marker tests and/or reveal the combinatory effect of loci [23].
RI evolves as the pleiotropic effect of loci under divergent natural selection, or the direct effect of loci in linkage disequilibrium [ 41].
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In fact, much of the effect of locus of control on labor market outcomes, in particular wages, may operate indirectly through the decisions individuals make to acquire productive skills (Heckman et al. 2006; Piatek and Pinger, 2010).
Note that the effect of locus frequencies in association mapping studies differs from typical QTL linkage mapping in experimental populations, where marker frequencies are under experimental control due to breeding designs and are often equal among alleles.
We extend these data to include examples of the effect of locus number.
Finally, we examined the effect of locus definition on the enrichment signal from Broad-Enrich.
In order to confirm the positive effect of locus 4, we established further congenic strains and analysed their total activity.
The GEBV of bull i, either in training or validation, was estimated as (1) where is the estimated SNP effect of locus k.
Because of the known confounding effect of locus length relative to the presence of ≥1 peak (Taher and Ovcharenko, 2009), we examined and observed a similar relationship between locus length and peak coverage proportion (Supplementary Fig. S1).
To investigate the effect of locus definition on enrichment signal, we ran Broad-Enrich for each of the 55 HM ChIP-seq datasets with the nearest TSS, exons and ≤5 kb locus definitions.
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