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The study was not designed to identify the magnitude of effect of individual interventions, and it remains therefore uncertain if the observed reduction in asthma is solely due to the reduction in tobacco smoke exposure or dietary alterations or a combination of both.
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Both meta-analysis and meta-regression techniques were carried out in order to synthesise the individual trial data for each intervention and then examine the effect of individual intervention characteristics on each outcome.
As a result, we were unable to dissect the effects of individual interventions (such has HAART for mothers versus co-trimoxazole for infants).
While there are studies evaluating the effects of individual interventions, less evidence exists on multimodal nonpharmacological approaches.
The quantitative data we obtain may be better geared towards providing evidence of the overall impact of regeneration programmes rather than untangling the effects of individual interventions.
We adjusted the analysis for baseline scores and categorical variables of trial and treatment allocation, which adjusted for treatment effects of individual interventions.
A fifth limitation concerns the assumption that the effects of individual interventions and their interactions will be similar for our countries, which may not be true as suggested by the differences observed between the overall set of countries and the African countries.
Lack of studies testing intervention components Analysis of the effects of individual intervention components is needed in future studies.
It may be that the application of several treatment strategies within one integral program weakens the effect of the individual interventions - especially when less thoroughly implemented (e.g. through fewer training hours) than in the original research studies.
To measure the effect of each individual intervention strategy, effect sizes were adjusted for other intervention components that appeared in at least one third of the studies on each strategy.
The effect of individual exercise intervention characteristics on both primary and secondary outcomes was explored by using the 'metareg' command in Stata (Version 14, StataCorp LP) [31] to perform univariate random effects meta-regression.
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