Sentence examples for effect of impairing from inspiring English sources

Since in both Six5−/− and Dmpk−/− mice, there is no trinucleotide repeat, these mutants can be used to differentiate between the direct effect of a gene and the effect of impairing the function of other proteins with which they interact.

Our results indicate that the effect of impairing SNO homeostasis in cancer cells depends on the intensity of the resulting nitrosative stress and also on the cellular context.

We see that lead has the potential to impact individuals' functioning across a wide variety of domains, with the ultimate effect of impairing the functioning of society.

FKBP51 has the overall effect of impairing GR nuclear translocation and reducing GR activity, and by down-regulating the GR signalling pathway, it exerts proliferative and anti-apoptotic properties (Denny et al, 2000; Romano et al, 2011).

This is reinforced by the special rapporteur: "Accordingly, international human rights law proscribes any discrimination in access to health care, and the underlying determinants of health, on the internationally prohibited grounds, including health status, which has the intention or effect of impairing the equal enjoyment of the right to health" (26).

It can test the effect of impairing factors on the overall performance of the communication process of a massive network of sensors.

We cannot exclude the possibility that the synthetic genetic interactions observed between the ART-Rsp5 network, GQC, and PMQC may result not from defects in sequential quality control systems but instead from nonspecific effects of impairing quality control at multiple organelles in the cell.

Correction of impaired efferocytosis in diabetic wounds and strategies to intercept the adverse effects of impaired efferocytosis emerge as novel targets for the management of chronic inflammation commonly noted in diabetic wounds.

Grade II waveforms are pseudonormalized (E greater than A) due to the opposing effects of impaired tissue relaxation and elevated left atrial pressure.

VDR null mice develop rickets and fail to undergo the first postnatal hair growth phase (anagen), resulting in alopecia and conversion of follicles into cysts with IFE differentiation [15], which is highly reminiscent of the effects of impaired epidermal Wnt signalling [16].

The metabolic effects of impaired mitochondrial utilization by pyruvate are also discussed.