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This short-term increased risk is consistent with an effect of HRT on one of the later stages of the process of breast carcinogenesis.
There was a trend over time with increasing duration of use of HRT, with no significant effect of HRT on overall risk of fracture in the first year of use, a 36% significant decrease in risk (8% to 40%) for one to two years of use, and a 45% decreased risk among women with 10 or more years of use (16% to 64%).
This study investigated the inhibitory effect of HRT on RANKL-induced osteoclastogenesis and whether the bacterial fermentation could affect this effect of HRT.
Our lack of a clear effect of HRT on the risk of oesophageal cancer is in contrast to a study which found that use of HRT, oral contraceptives, and age at menopause were all inversely related with the risk of oesophageal squamous-cell carcinoma (Gallus et al, 2001).
It neither attenuated nor potentiated the effect of HRT on lipids and lipoproteins.
We investigated the effect of HRT on liver enzymes, lipid levels and measures of insulin sensitivity 26 in hypopituitary women.
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Besides the apparent protective effects of HRT on the heart, estrogen replacement also caused a reduction in bone-thinning osteoporosis, reducing the risk of fractures that can be so devastating in older women.
Additionally, the CFD model proposed can enhance the fundamental understanding of the effects of HRT on separation efficiency and at the same time, probably coupled with physical experiment whenever necessary, offer a more reliable way for optimum control of HDVS under varying conditions.
To evaluate the effects of HRT on small blood vessels, we assessed the relationship between use of hormone replacement therapy (HRT) and retinal microvascular diameter in older women in the Blue Mountains Eye Study baseline population (n = 1993, age >/= 49 years).
Thus, there will be a continued need for observational data to look at the effects of HRT on disease.
Comments included: "My answers have been based on the conceptions (? misconceptions) I have gained from observing effects of HRT on my wife" (age 72).
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