Sentence examples for effect of genomic variation from inspiring English sources

Especially in the context of interrogating whole exomes or even whole genomes, and with increasing knowledge about the effect of genomic variation, identifying the multiple dimensions of a genetic diagnosis becomes urgent, especially if other variants than those related to the clinical phenotype are to be considered as part of comprehensive diagnosis.

A systems understanding of disease and drug action at the level of cellular biochemical reactions and physiological function would be useful in framing the effect of genomic variations in the context of environmental cues.

New methods to simultaneously amplify and sequence genomic DNA and full-length mRNA from the same cell may provide powerful tools for assessing the effects of genomic variation on gene expression profiles [96, 97].

The amount of phenotypic information derived from targeted mutations and hypothesis-driven studies is increasing rapidly, and is now being further augmented by high-throughput international efforts to systematically analyse the effects of genomic variation on model organism phenotypes.

New methods are needed in four areas to realize the potential of personalized medicine: (i) processing large-scale robust genomic data; (ii) interpreting the functional effect and the impact of genomic variation; (iii) integrating systems data to relate complex genetic interactions with phenotypes; and (iv) translating these discoveries into medical practice.

HAT-RAPD (High Annealing Temperature-Random Amplified Polymorphic DNA) was applied for analysis of genomic variation in the mutant.

There is enormous heterogeneity in types of genomic variation that occur in human disease.

But other kinds of genomic variation turn out to be at least as important.

The genetic history of sheep has been investigated using three major sources of genomic variation.

examines the richness of genomic variation and its implications.

The study of genomic variation within species has focused primarily on variation in nucleotide sequence.