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To our knowledge, no study has systematically investigated the effect of genetic variations within inflammation-related genes and risk of normal tissue toxicity due to radiation therapy.
Thus we need to further investigate the effect of genetic variations on transcription activities.
However, the effect of genetic variations of DDAH1 on type 2 diabetes has not been reported.
Patients in Group III were part of a prospective cohort study determining the effect of genetic variations in innate immunity receptors on the cortisol response postoperatively.
The genetic component of this study was designed to investigate the effect of genetic variations on the activity of antioxidant enzymes.
This is the first study, to our knowledge, revealing the effect of genetic variations of intron 1 SNP rs9939609 of FTO on the risk of tuberculosis.
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In one study by H. Lei and colleagues, resting-state fMRI was integrated with genetics to examine the effect of genetic variation of the MAOA gene on resting brain activity in healthy male adolescents.
Imaging genetics is a research methodology studying the effect of genetic variation on brain structure, function, behavior, and risk for psychopathology.
A recent effort to quantify the effect of genetic variation on gene expression found that SNPs and CNVs contribute 83.6% and 17.7% of the total variation found [16].
We explored the main effects of single SNPs and also the cumulative effect of genetic variation within the inflammation pathway on toxicity risk.
We estimated the effect of genetic variation on CHD, ischemic stroke and the composite end-point of CVD in two prospectively followed population cohorts.
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