Sentence examples for effect of genetic alterations from inspiring English sources
A mathematical description of normal tissue regeneration may identify immortalization (defying programmed senescence and cell death) as an early deviation from the physiological process with a potential for oncogenesis as a result from a combined effect of genetic alterations and environmental stimulations [8].
Development of mOGCT may involve the combined effect of genetic alterations or predisposition and disadvantageous environmental factors such as exposure to maternal hormones, external endocrine disruptors, or adverse lifestyle-related factors that disturb the cells' normal biochemistry.
Human disease studies are being supplemented by engineered mouse mutant studies, which give access to the effects of genetic alterations unlikely to occur naturally.
Based on these results, we could speculate about potential diversity of structural mechanisms that may be associated with the effects of genetic alterations.
Ultimately, quantitative analysis of immune responses can facilitate discovery in settings where gene modification is impractical, as in primary human cells, or where the direct and indirect effects of genetic alterations mask subtle or unanticipated interactions (Sontag et al., 2004).
To understand the functional importance of the interactions between ARF6, BZR1, and PIF4, we analyzed the effects of genetic alteration of each component on the growth responses to changes in the other activities.
Yet we know little on the initial pathway involved in areca-nut associated carcinogenesis since it is difficult to assess its effects on genetic alterations without interference of other compounding factors.
Xenotransplantation models enable the propagation and analysis of primary human samples but may be difficult to interpret due to variability of genetic background, the effects of immune recognition, a limited knowledge of genetic alterations in samples before and after xenotransplantation, and incomplete interaction with the microenvironment.
Suppression of replication stress likely contributes to the protective effects of quiescence to counter age-dependent accumulation of genetic alterations.
Generating a comprehensive list of genetic alterations that ameliorate the effects of aneuploidy and their characterization will shed light on tumor evolution.
Cancer progression is driven by the accumulation of a small number of genetic alterations, together with the collective effect of tens of thousands of additional mutations termed passengers.
