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Distribution of RE for GC-treated and EtOH-treated samples are nearly the same, implying no global effect of GC on translational efficiency of the genes.
The effect of GC on cytokine production, either pro or anti-inflammatory, is dependent on both the dose and duration of GC exposure.
Co-culture with β-AET countered the suppressive effect of GC on LPS-induced TNFα and IL-1β secretion.
In RA this negative effect of GC on bone has been questioned.
We also investigated the effect of GC on epithelial mesenchymal transition-related markers.
Surprisingly, previous results came as the negative effect of GC on fibroblasts proliferation and the ability of synthesizing mature collagen.
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More recently, a diminished inhibitory effect of GCs on PBMC proliferation in vitro was shown in a larger cohort of GC resistant RA patients [ 3].
Furthermore, we demonstrate a direct, GR-dependent effect of GCs on NSC differentiation into oligodendrocytes, which involves an upregulation of pro-oligodendrogenic genes, and increased nuclear localization of Olig1 protein.
In this experiment, PC axons did not change significantly their growth pattern (Fig. 4E, E17+GCflipflip vs E17, Chi square or Fisher exact tests always P>0.30), showing that the main effect of GCs on the growth mode of PC axons is exerted through contact-mediated factors, while high KCl concentration has no overt influence.
In this study we investigate the effect of GCs on mRNA translation on a genome-wide scale.
Another direct effect of GCs on osteocytes is the induction of apoptosis through activation of caspase 3 [ 34].
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