Sentence examples for effect of fad on from inspiring English sources
To determine whether autophagy contributes to FAD-induced cancer cell death, we examined the effect of FAD on the induction of LC3-II.
Although that study did not examine effects on plasma E2 concentrations, it was noted that the responses would favor increased synthesis of E2 to potentially offset the effect of FAD on aromatase.
The effects of FAD on ex vivo E2 production, plasma E2, and plasma Vtg in female fathead minnows were consistent with FAD's anticipated mode of action.
The model predictions of T and E2 were compared to published effects of FAD on E2 steroid production by ovaries in ex vivo assays [ 39].
To further determine whether FAD can kill different types of cancer cells, we tested the effects of FAD on several cancer cells derived from different tissues (MDA-MB231, MCF7, DU145, MonoMac6, Raji, and KOPN-1) as well as non-transformed MCF10A and IEC6 cells.
Another set of compounds, such as fenofibrate, mimicked the effect of FAD mutations by increasing Aβ42 production [13], [25].
Next, we wanted to determine the effect of FAD-linked mutant APP on ER calcium store size.
We therefore suggest that there is a differential effect of FAD-linked PS1 mutations on γ-secretase-dependent neurexin processing, as it is the case for other substrates.
To determine the effect of FAD-linked APP mutants on receptor-operated calcium entry, we waited until cytosolic calcium levels reached baseline following UTP stimulation in calcium-free medium and replaced the bath solution with calcium-replete medium.
However, it should not be overlooked that conflicting results also indicate the absence of a direct effect of fAD-linked APP mutations on [Ca2+]i levels and/or Ca2+ release from intracellular stores.
These results are supported by studies showing heterogeneous effects of FAD PSEN mutations on the Aβ42 40 ratio depending on the mutation [ 156- 158], but are contradicted by reports of universal increases in Aβ42 as a result of FAD mutations [ 153, 159].
