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Analyzing the reaction thermodynamics within the dense, collapsed bubble, it can be said that the effect of excluded volume of the non-ideal gas results in pronounced suppression of the molecule-producing endothermic reactions using Le-Chatelier's principle.
The effect of excluded volume (EV) and hydrodynamic interaction (HI) on a dilute solution of flexible polymer chains situated in a shear field has been studied by means of a Brownian dynamics simulation.
Here, we focus on the effect of excluded cosolutes on protein aggregation processes.
The effect of excluded cosolutes has previously been attributed to the large volume excluded by such inert cellular solutes, sometimes termed "macromolecular crowding".
Aside from the effect of excluded volume on the energetics and kinetics of intracellular reactions, it could be hypothesized that in a crowded milieu, there would be many interactions between unrelated proteins.
To this end, we focus on the structure of networks obtained from Lennard-Jones clusters and clusters imposed on HCP lattices (to test influence of excluded volume on the results) as well as polybutadiene melts (to test the combined effect of excluded volume and chain connectivity).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com