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While not in this case, the beneficial renal effect of discontinuing lithium is observed mainly in patients with moderate chronic kidney disease (creatinine clearance >40 mL/min) (Baig et al. [2011]; McKnight et al. [2012]).
A 4-week randomized withdrawal (RW) period was included in this trial to assess the effect of discontinuing treatment with linaclotide.
23 This double blind randomised controlled study aimed to investigate the effect of discontinuing maintenance treatment in a group of first episode patients who had completed at least one year of antipsychotic drug treatment with no relapses.
The effect of discontinuing darbepoetin alfa on the trajectory of the rise in haemoglobin was assessed in patients who met prespecified haemoglobin thresholds (14.0 g dl−1 for women and 15.0 g dl−1 for men).
In addition, a formal trial studying the effect of discontinuing treatment once remission is achieved or after a certain period of time might be interesting, in the light of the different mechanisms of action of co-stimulation blockers as compared with TNF-blocking agents.
The effect of discontinuing ADA on clinical disease activity, functional disability and radiographic progression were evaluated by DAS28 (ESR), the clinical disease activity index (CDAI) and the simplified disease activity index (SDAI), by a health assessment questionnaire-disability index (HAQ-DI) and by the modified total Sharp score (mTSS), respectively.
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Research studies on the effects of discontinuing antipsychotic medications in patients with dementia have not identified specific target symptoms or response to antipsychotics prior to discontinuation.
Our study shows the metabolic effects of discontinuing ART.
As a next step, the possible effects of discontinuing hypnotics were investigated.
During the subsequent six months follow-up, the effects of discontinuing the intervention on depot acceptance will be assessed.
At the end of 2 years, a 1-year extension study was carried out to further assess ODN efficacy, safety, and the effects of discontinuing therapy.
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