Even though miRNAs repress the protein output of their target genes as a combined effect of mRNA destabilisation and translational repression, a recent study has reported transcript destabilization to be the main contribution to miRNA target deregulation [ 46].
We note that a consequence of destabilisation of DNA breaks is increased DNA end-to-end fusions [ 25].
In vertebrates, alpha-latrotoxin produces its effect through destabilisation of cell membranes and degranulation of nerve terminals, resulting in excessive release of neurotransmitters, namely acetylcholine, norepinephrine and GABA.
Bonincontra et al [18] and Calandrini et al [19] reported that although the general effect of IPA treatment was destabilisation of the macromolecular structure, the collagen conformation had changed, resulting in alteration of the collagen molecular dimensions.
Degron tagging of ERG20 was therefore paired with a sterol responsive promoter to ensure sufficient metabolic flux to essential downstream sterols despite the severe destabilisation effect of degron tagging.
This data illustrates that the destabilisation effect of imperfect peptides upon a helix is dependent upon the location of the imperfection, and that if helicity is the goal, removal of helix-disrupting imperfections by gel filtration may be more effective than direct purification of an unfolded peptide.
Rather, the main ecosystem engineering effect of A. marina is hydraulic destabilisation of the sediment matrix.
The apoptotic effect of α-TOS involves lysosomal and mitochondrial destabilisation as well as caspase-3 activation (Alleva et al, 2001; Neuzil et al, 2001b).
The transcript number would be expected to be similar in both daughters immediately after GSC division, with any effect of Brat on deadenylase recruitment and transcript destabilisation first requiring time for the Brat protein to accumulate in the CB.
It began a process of destabilisation.
