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An unexpected finding was the apparent lack of effect of descending control from the PAG on the number of nociceptor-evoked Fos-positive neurones in lamina II.
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As described in the text, we also controlled for the effects of descending axons when such were present.
The electrophysiological characteristics of motor neurones, and the effect of the descending pathways on the pool of spinal motor neurons, explains the increase the activity of those innervating the FT once the AT has been reached [ 29].
An implication of these observations is that in a subduction zone water has a greater effect on solidus temperature of descending crustal material near the slab/peridotite interface than in an overlying peridotite wedge or in an underlying depleted oceanic lithosphere (200°C to 300°C temperature difference; Kushiro et al. 1968b; Grove et al. 2012).
Whether the exogenous BDNF has any effects on the regeneration of descending neurons needs further investigation, but this is likely as we found more GAP-43 labeled fibres in the injury site in the BDNF treated group than the BSA group (Figure S6).
Exercise has been demonstrated to produce widespread hypoalgesia effects, perhaps through enhancement of descending pain inhibition.
The lack of effect on the RIII reflex suggests that such analgesic effects may not depend on the activation of descending inhibitory systems.
This undesirable effect can be counter balanced by application of sucrose solutions of descending concentrations [ 45].
In our study, we found a robust line of descending tendency with age only for parent ratings; the effect size for teacher ratings was negligible.
Cumulative analysis, in which studies were added in order of descending variance on odds ratios, was done to rule out a potential small-study effect.
Models were subsequently ranked in order of descending GPI.
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