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To determine the direct pathogenic effect of CRP on bone destruction in RA, we studied the effect of CRP on the production of RANKL from monocytes, which is a key molecule in osteoclastogenesis in RA.
These findings argue against a causal role of CRP in atherogenesis and are consistent with a protective effect of CRP on EDNO bioavailability.
Genetic variants that are known to be associated with CRP levels can be used to provide causal inference of the effect of CRP on CHD.
To investigate the potential mediating effect of CRP on the association between types of meat and type 2 diabetes, baseline ln(CRP) (mg/dL) was added to model 2 as an additional covariate.
Medication was added to the Cox-regression to examine whether it affected CRP or changed the effect of CRP on BD progress.
They are consistent with reverse causality in the association of CRP with atherosclerosis and a protective effect of CRP on NO availability.
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Fifth, the most important limitation is that the instrumental variables analysis provided wide confidence intervals for the effects of CRP on CIMT suggesting that larger samples are needed to obtain more precise estimation.
We studied the effects of CRP on the induction of RANKL and osteoclast differentiation from peripheral blood monocytes.
Exposure-response modeling demonstrated small, reversible effects of tofacitinib on mean SCr, and significant (P <0.05) effects of CRP on model parameters.
Based on these mechanisms, differences in the effects of CRP on CVD risk could be hypothetically observed in people with and without diabetes (with a less favorable risk for the former) as the result of differences in the pathological processes responsible for increased CRP in people with and without diabetes.
Our study also has major strengths, including its large sample size and number of deaths recorded, our ability to directly compare the effects of CRP on mortality risk in people with and without diabetes, and our ability to assess the possible effects of sex and other cardiovascular risk factors on the observed relationships.
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