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The small number of individuals with two copies of the Hp haplotype E did not allow us to assess whether there might be a dose effect of carriage of this haplotype on risk of trachoma.
This supports our earlier hypothesis that this polymorphism is under some selection pressure (similar to HbS), possibly from a deleterious effect of carriage of two copies of the C allele, resulting in the absence of -61C-C homozygotes.
In Table 3 Models 2, adjusting for a number of known risk factors for TB (baseline BMI, absolute CD4 cell count, age, sex) considerably modified the magnitude of effect of carriage of the TB predisposing minor allele for SLC1 (rs34448891) and SLC3 (rs3731865), however, these associations were not statistically significant.
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When analyzed separately, the effects of carriage and infection did not differ between ESBL-producing Escherichia coli (48.7% of carriage isolates) and other ESBL-E.
Several hypotheses have arisen including the effects of carriage processes [ 21], vaccine replacement [ 25] or the presence of new allelic recombinations [ 38].
The meta-analysis of results from three populations confirmed a modest but significant effect on carriage of c5-155C (odds ratio = 0.64; 95% confidence interval [CI] 0.44 0.94) and c5-142A (odds ratio = 0.66; 95% CI, 0.45 0.94) variants in reducing the risk of RM.
We did not observe any difference between vaccine schedule groups in their effect on carriage of vaccine or nonvaccine serotypes at either 18 or 36 weeks.
Vaccines exist for serogroups A, C, W135, X and Y but no commercial vaccine has yet been produced for serogroup B. Limitations of the vaccines are short duration of immunity, 3 5 years, low immunogenity in children under two years and no effect on carriage of the bacteria (24, 25).
Two showed a beneficial effect, two a detrimental effect of FVL carriage, and one showed no effect of FVL carriage on outcome from severe sepsis [ 8- 13, 14] 14].
The competition parameter, cV (the relative susceptibility of NVT carriers, compared with uncolonised individuals, to acquiring VT carriage), was assumed to be 50% since there is little information from post-vaccination surveillance on the protective effect of NVT carriage on VT acquisition.
Increased variability in the acceleration of the head and in the transmission ratios suggest a potentially destabilizing effect of load carriage on the head trajectory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com