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There are potential explanations for the lack of effect of CAP on health end points in 1-day exposure studies.
In the Health Professionals Follow-Up Study, endodontic treatment was used in conjunction with CAP as an indication of the presence of pulpal infection, so the effect of CAP on the probability of coronary heart disease, with an odds ratio of 1.21, was probably underestimated in this study [ 17].
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To confirm this, the effect of CAPs on tumors with high and low HS expression should be explored with in vivo studies.
Using a robust randomized, double-blind sham-exposure study design, we have assessed the effect of CAPs on two complementary aspects of vascular function.
Using flow-dependent dilation as an indirect index of endothelial function, Brook et al. (2002) found no effect of CAPs on endothelium-dependent dilation.
In linear models including main effects for stress exposures and age, with separate slopes for CAPs mass concentration exposures by stress group (Table 4), the effect of CAPs on respiratory function was qualitatively different by stress group.
The modulatory effects of CAP on proinflammatory cytokines also alter when the challenge route of pathogens is different.
Hence, to understand the effects of CAP on EPCs, we first examined the time course and reversibility of the response.
Most experiments regarding the modulatory effects of CAP on inflammation were tested in the models of sepsis, a syndrome of systemic proinflammatory responses.
Here, we emphasized the research regarding the modulatory effects of CAP on animal models, cell population, and signaling pathways that involved in the pathogenesis of ALI.
Thus, future studying local modulatory effects of CAP on inflammation may be an emerging avenue to explore how vagus nerve senses, recognizes, and responds to pathogens.
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