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Under such conditions, the effect of an activating microenvironmental stress becomes a crucial trigger.
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Therefore, stimulating hERG1 channel activity could be preparatory for more efficacious effects of an activated immune system and/or antiproliferative drugs.
More elaborate target functions can also be used to represent situations in which the effect of a specific activating or inhibiting edge is dependent on the level of additional proteins.
In case of simulation of the effect of activating a target gene, its expression level values may be increased to the desired value.
Succeeding in constructing a network out of simplified neuronal elements means that the effect of activating a connection between two real neurons on the output of the postsynaptic neuron will be the same in the model.
The effect of activating a competitive ADP trap consisting of pyruvate kinase (PK) and phosphoenolpyruvate (PEP) was assessed in two ways: first, as has been done earlier (12), with PEP in the solution from the beginning of the experiments (see Fig. 2 C), and second, with PEP and exogenous PK added consecutively after stimulation with 2 mM ATP (see Fig. 2 D).
The study presented here provides the description of a manual protocol for producing two kinds of canine PC arbitrarily classified as lower fraction (PC-A) and upper fraction (PC-B) and evaluates the effect of a non-proteic activating substance (calcium gluconate -CG-) and the combination of a proteic activating substance (batroxobin) plus CG on the release of TGF-β1 from canine PC.
To determine the effect of PUM2 on activating Aurora-A, an in vitro kinase assay was performed to measure the activity of Aurora-A by using Histone-H3 as a substrate.
The pro-aging effect of chronically activating these pathways from an early age probably increases the age-associated risk of many adult diseases in tandem with overweight and obesity, including ones whose tie with adiposity has only recently become apparent, such as dementia [ 77].
To interpret Eq. (2), consider the average effect of a bilateral CI activated at age a2.
All of these studies proved a strong irritation effect of TRPA1 activating substances.
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