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The moderating effect of adherence to treatment also is unknown.
To evaluate the effect of adherence and condom use on apparent efficacy of microbicides.
References. 1. McEvoy MD (2014) The effect of adherence to ACLS protocols on survival of event in the setting of in-hospital cardiac arrest.
To test this hypothesis, we examined the effect of adherence on viral load after different durations of viral suppression.
We used marginal structural models to estimate the effect of adherence during a given month on the probability of virologic failure at the end of that month.
For example, among participants who had maintained viral suppression for exactly 4 consecutive months, we estimated the effect of adherence during month 5 on the probability of virologic failure at the end of month 5.
Marginal structural models and targeted maximum likelihood estimation methodologies were used to determine the effect of adherence to antiretroviral therapy on the probability of virologic failure during early and late viral suppression.
The effect of adherence on the probability of virologic rebound was estimated by calculating the exact odds ratios (ORs) and their 95% confidence intervals using univariate exact conditional logistic models, to account for the small sample size with sparse data[11].
A systematic effect of adherence on survival is not evident.
Post-hoc analyses were conducted to evaluate the effect of adherence on adaptation.
Survival analysis was used to determine the effect of adherence on all-cause mortality.
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