Sentence examples for effect of abused from inspiring English sources
The underlying reasons may be the following: effect of abused drugs on the orexin system was drug-specific [ 24], and regional variations within the LH have been reported in response to some drugs.
It is to our knowledge unknown if the response to psychostimulants is changed in subjects with PTSD, or if there are sex differences in the acute effect of abused drugs in people suffering from major depression or PTSD.
Most importantly, endocannabinoids exert pronounced influence on primary rewarding effects of abused drugs, including exogenous cannabis itself, through the regulation of drug-induced increase in bursting activity of dopaminergic neurons in the ventral tegmental area (VTA).
Dopaminergic neurons play a key role in the dependence-inducing effects of abused drugs [22].
With novel and precise cannabinoid probes, our results indicate the expression of brain CB2-Rs in mouse model of depression and in the effects of abused substances [20].
Altogether, these results revealed the functional presence of brain CB2-Rs that plays a role in the effects of abused substances.
To further improve understanding of the role of CB2-Rs in the brain, we hypothesized that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances in rodents.
In this study we tested the hypothesis that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances including opiates, cocaine and ethanol in rodents.
The effects of abused drugs on ENK and DYN in the CeA and BST are complex.
ΔFosB, which accumulates slowly after each drug exposure, seems to mediate the positive rewarding and sensitizing effects of abused drugs.
Sex differences in cholinergic function in the striatum are likely to contribute to differences in the effects of abused drugs.
