Sentence examples for effect of abrogation from inspiring English sources
We then examined the effect of abrogation of E-cadherin function on the activity of the EGFR/ERK and PI3-K/AKT pathways.
This work elegantly and systematically describes the effect of abrogation of the gamma secretase component Aph1B in synaptic transmission, plasticity, and dendritic spine formation, and provides convincing data pointing towards the neuregulin 1 intracellular domain as a downstream regulator of these events.
OBJECTIVE: We sought to determine the effects of abrogation of lymphoid tissue expression of CCR7 agonists on allergic airway responses.
A very novel and interesting part of the work was the in utero electroporation to obtain single cell conditional deletion of Aph1BC, and thereby investigate the effects of abrogation under physiological conditions in a wild-type background.
Next, we addressed the effect of Trf1 abrogation in immortalization of MEFs.
The role of p53-family members in the transcriptional regulation of NIS expression was further confirmed by the strong effect of the abrogation of p53, p63 and p73 expression by specific siRNAs (Supplementary Figure S3) on NIS promoter activity.
Using one such cell line, K1, we have tested the effect of experimental abrogation of p53 function by generating matched sub-clones stably expressing either a neo control gene, a dominant-negative mutant p53 (143ala) or human papilloma virus protein HPV16 E6.
To assess the effect of Trf1 abrogation in the context of lung cancer induced by expression of the K-Ras G12V oncogene, we crossed K-Ras+ /LSLG12Vgeo mice (designated from now on as K-Ras+ /G12V ) (Guerra et al, 2003) to a strain carrying a floxable allele of Trf1 (Trf1 lox/lox ) either wild-type or deficient for p53 (p53−/−) (Martinez et al, 2009) (Fig. 1A).
Next, the in vivo effects of combined abrogation of JAK2 activity by TG101209 and Bcl-2/Bcl-xL by ABT-737 were assessed.
Intriguingly, even though Tubb3, Scn2a and L1cam are all Rest target genes, their expression were not de-repressed in REST-null ES cells during early ES cell differentiation (Fig. 2F 2H), a view consistent with the absence of any effect of acute Rest abrogation on expression of these genes in ES cells (unpublished observations).
