Sentence examples for effect of a variant from inspiring English sources

It has already been noticed that the individual effect of a variant can be too weak to be detected individually and that interactions of multiple SNPs within the same gene can affect a phenotype [35].

The genotypic effect of a variant on the change over time in the CDR sum of boxes was assessed using a repeated measures mixed model, with covariates of baseline CDR sum of boxes, baseline MMSE, sex, age at baseline and APOE4 status, with genotype and the genotype*time interaction as the factors of primary interest.

Even if the effect of a variant is small, the pathway it leads to could be of major importance.

Finally, DNA editing strategies involving CRISPR/Cas9-based methods can be employed to evaluate the effect of a variant.

In contrast to disease, the prediction of the effect of a variant upon molecular function focuses only on the native function of one particular protein.

In genomic medicine, one does not wish to know the population average effect of a variant at a locus, but rather the effect of one's particular genotype.

Since in most cases there is no solid and comprehensive basis of experimental data that would allow for a more sensitive classification, we suggest that the best available indication of distinct effects of a variant on two diseases is the signal itself being different.

A further candidate gene approach revealed the modifying effects of a variant in the TCF7L2 gene 91 that associates with both type 2 diabetes and CF-related diabetes, supporting the concept that diabetes develops in patients who may have underlying susceptibility to β-cell dysfunction.

Locus-by-locus approaches for statistical analysis are well developed for such designs to evaluate the main effect of a genetic variant and simple interactions between genetic variants.

A further note of caution: while it is generally assumed that common variants associated with disease in GWAS reflect the effect of a causal variant in close proximity, this is not necessarily so.

The basic reasoning is that it may be easier to detect the effect of a genetic variant on a more elementary neurobiological trait because there may be fewer genetic variants with larger effect sizes involved in these traits.