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In this study, we examined the effect of a spectrum of common and rare amino acid substitutions of DISC1 associated with psychiatric illness on the nuclear targeting of the protein.
This facilitates investigation of the functional effect of a spectrum of drugs on representative cell models and may be developed as a tool for cancer diagnostics and personalized medicine in the future (Barretina et al., 2012, Garnett et al., 2012, Pemovska et al., 2013, Shoemaker, 2006, Tyner et al., 2013, Yang et al., 2013).
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Three, we obtained evidence for the same genetic effect on a spectrum of most commonly examined risky behaviors.
To determine the target biological pathways for each small molecule, we developed a novel framework for encoding small molecule effects on a spectra of biological processes or GO functions that are enriched in the differentially expressed genes of a given small molecule perturbation.
We also sought to determine the most informative SNPs for potential genetic screening and personalized medicine, since the MYH9 risk alleles are both highly frequent and have strong effects for a spectrum of common renal diseases (2, 3, 7, 9).
The present study was designed to assess gene expression in human reconstructed skin following exposure to DUVR and the protective effect of a broad spectrum sunscreen.
Since it is known that HB-EGF is released by metalloproteinases (47), we examined the effect of a broad spectrum inhibitor, GM6001, and two tissue inhibitors of MMPs (TIMP-1 and TIMP-3) on proliferative response to uPA.
A general function for metalloproteinases in thymic T cell development was determined by assessing the effect of a broad-spectrum metalloproteinase inhibitor.
Using this approach we were able to create a range of definitions of diarrhoea and analyse the effect across a spectrum of disease as well as allow comparison with previous trials.
The credibility of evidence is established by demonstrating a similar protective effect across a spectrum of ten risky behavior traits measured on the same set of individuals.
This study tests a specific hypothesis: The 9R/9R genotype in the VNTR of the dopamine transporter gene exerts a general protective effect against a spectrum of risky behaviors in comparison to the 10R/9R and 10R/10R genotypes.
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