6, 19, 42 Ultimately, the effect of a mutation on the contraction of the cardiac muscle will depend on the mutated gene, the location of the mutation within the gene, and consequently on the protein and the abundance of the mutated protein within the myocyte.
Fisher had shown, by a geometrical argument, that the larger the phenotypic effect of a mutation, the less likely it is to be advantageous.
Epistasis is the dependency of the effect of a mutation on the genetic background in which it occurs.
The other, Zelboraf, from Roche and Daiichi Sankyo, blocks the effect of a mutation in a gene called BRAF.
If cancer is such a complex system, how can one ever predict the effect of a mutation in a particular gene on a functionality of the entire system?
In particular, the drug counters the effect of a mutation in a gene called B-RAF that was discovered in 2002 to be common in melanomas.
Modeling the functional effect of a mutation is, however, a nontrivial task, due to strong functional interdependencies.
Therefore, we developed a web server named the Kinase Resistance Docking System (KRDS) that allows researchers to easily evaluate the effect of a mutation on drug binding.
The effect of a mutation on the phenotype is not a property of a gene but rather differs across the different genetic backgrounds in which it occurs, depending on what other gene variants are present in the genotype.
The latter fact also demonstrates that the effect of a mutation on the proteome is highly age- and tissue- dependent.
However, we found that the relationship between female preference and relative gamete mutation load was independent of the size of the effect of a mutation.
