One protein's presence can have a drastic effect on a multitude of proteins and pathways and the interrelationships between seemingly unrelated proteins and pathways is only now coming to light [10].
Adipocytokines have physiological effects on a multitude of metabolic pathways and are altered in the presence of increased fat mass, particularly abdominal obesity, e.g. elevation of certain adipocytokines, such as leptin, and decrease of others, such as adiponectin (6).
This will have tangible effects on a multitude of factors such as health care delivery and insurance [6] [7].
A more comprehensive list of AMPK's actions can be found in a recent review by Ruderman et al. 3 AMPK activation has effects on a multitude of tissues.
Seen through Mr Bergsten's rose-tinted glasses, the trade effects of a multitude of PTAs can be gauged simply by adding up, as it were, the series of partial liberalisations.
A less densely packed protein layer indicates a minor interaction of the proteins with the gelatin-based hydrogel and might lead to a lower risk of rejection of the implant and better biocompatibility and hemocompatibility, although additional effects of a multitude of other parameters have to be taken into account to predict possible consequences, depending on the particular in vivo situation.
For example, even though a gene is relevant to a pathway under investigation, its knockdown does not need to have an effect for a multitude of reasons, such as the paralogue issue and the alternative/branching of pathway issue.
The GWA approach has seen much success over the last few years, identifying many novel genetic effects for a multitude of human disease phenotypes [ 2].
During the last decade, many effects involving a multitude of methods has been made to the determination of the interactions between drugs and their targets.
The theory showed that mass makes spacetime curve, an effect that has a multitude of implications.
