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In this study, we clarify that this effect is triggered by stress kinases JNK1/2 and p38 activation.
Modeling the pharmacokinetics of the drug, we found that the toxic effect is triggered by a blood concentration of 1.9 3 pM.
It is believed that the early secretion (which accounts for most of the effect) is triggered by local nutrient-sensing pathways and neuronal and endocrine mediators, while the late-phase release is produced by a direct nutrient contact (3– 5).
To find out whether this effect is triggered by apoptosis, necrosis or simply by endothelial cell cell contact disruption, a migration assay was performed as described above, in which cells were stained with AnnexinV/PI and measured in the Multiplate Reader.
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This effect was triggered by Drp1 phosphorylation and ultimately resulted in reduced respiratory capacity.
Interestingly, it was not the length of of a jail sentence, or even the length of the term of probation that were found to be significant; rather, the effect was triggered by being given these sentencing options.
Overall the interactive effects of the different climate variables explained by far the largest proportion of the variation in leaf out timing across all temperate tree species where more than 75% of climate effect was triggered by climate interactions.
One of the possible and potentially dangerous cardiotoxic effects is triggered by drugs acquired long QT syndrome (LQTS) which can lead to the fatal ventricular arrhythmia what effected in withdrawal of several drugs from the market.
These effects are triggered by fast horizontal arm tracking maneuvers driving the pendulum substantially away from the initial equilibrium point.
Those lowering effects were triggered by a condensed phase CB-iodine oxides reaction explored by high heating rate time-resolved temperature-jump time-of-flight mass spectrometry and low heating rate thermogravimetric analysis/differential scanning calorimetry results.
The examination of the experimental data indicates that charge redistribution and glass transition peaks share the same origin, and that the conduction aging effects are triggered by the onset of the glass transition.
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