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As the name indicates, the chemical dose that causes no adverse effect is selected for further computation of the risk.
We first consider that in the interim analysis the treatment group m with the largest observed interim effect is selected for the second stage, setting for.
Following the lines of Graf and Bauer (2011), the conditional type 1 error rate 1994 for this scenario simplifies to 3Note that if the treatment with the largest observed interim effect is selected, m is random and therefore also is a random variable.
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Then the positive transformants with high inhibitory effect were selected to express in shake flasks (1-l shake flask containing 200-ml BMGY medium) using the same method.
Ductile and shear criteria with an isotropic plastic-damage model considering the strain-rate effect were selected in the FE models to simulate the failure and damage processes at the meso-scale levels.
Four bacteriocinogenic LAB strains, Arla-10 (GenBank accession number JX275803), JFR-1 (GenBank accession number JX275814), JFR-5 (GenBank accession number JX275817) and TSB-8 (GenBank accession number JX275827), isolated from cheeses and yogurt products with anti-listerial effect were selected (Yang et al. 2012).
Of several sequences tested for PGC-1α knock-down, the sequence with the best interfering effect was selected as described previously [24].
SNPs composing the polygenic effect were selected by forming 400 k-means [41] clusters of SNP markers from Barley CAP genotype data and selecting the SNP nearest the centroid of each cluster.
Thus, the experiments with lowest PDT effect were selected as representative results.
The dose used to produce analgesic effect was selected, as it may be linked with the anti-inflammatory activity of the extract.
In these cases, the transcript associated with the most significant CR (or aging) effect was selected, and the remaining (less significant) transcripts were discarded from further analyses.
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