Our results support the involvement of this miRNA in cardiac aging since it was both characterized as age-dependent and included in consensus modules; nevertheless its synergism effect was not substantial (relations including miR-34a were over 399th rank).
From the different distributions it is seen that electrostatic effects are not substantial for Pt(100), minor but significant for Pt(110) and quite important for Pt(111).
From the time-evolution of the species mass fractions, it is found that transient effects are not substantial for radicals such as OH and H, and species such as CO,CO2 and C2H2, consistent with their small characteristic chemical time scales.
Another inhibiting factor may have been related to the same trough that caused the northward turn, though due to a large anticyclone situated over the hurricane, the weakening effects were not substantial.
Recently completed phase III trials first demonstrated a survival benefit of docetaxel-based combined regimen in patients with hormone-refractory disease, but these improved effects were not substantial (Petrylak et al, 2004; Tannock et al, 2004).
The evidence for amitriptyline's beneficial effect is not as substantial as the others but should be taken in context with decades of its perceived success in FMS treatment [ 19].
There were, however, only 14 deaths in this category and so the effect on the estimate is not substantial.
In addition, although loss of precision is an issue, it may also be viewed by some as yielding more conservative estimates of effect particularly if this loss is not substantial, as is the case for SIMEX.
Explicit evidence is helpful when substantial effect is not visible to the naked eye. See Lopez, 514 U.S., at 563.
