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Overall, we believe the network effect is more relevant than ever to future startup success.
The former effect mainly affects weak intensities whereas the latter effect is more relevant for stronger total signals.
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2,5-HD inhibited the rate of ATP synthesis mediated by both the respiratory complexes, although its effect was more relevant for complex I.
We report here that the 2,5-HD effect was more relevant in the presence of the complex I substrates, having observed that the LHON cybrid cell line carrying haplogroup U was still the most resistant, whereas no difference between cybrid cell lines was observed with the complex II substrate succinate.
Furthermore, the inclusion of cantonal fixed effects is more relevant than random effects when considering the whole population, i.e. the 26 Swiss cantons.
Interaction effects were more relevant with the contingent ranking model, suggesting that CV is a more limited approach in a context of multiple valuation.
We also show that, in the case of flecainide, the INa blocking effects are more relevant to wave reduction under our experimental conditions than RyR2 stabilization.
Hohoff and colleagues found that its effect on anxiety was stronger at the lower amphetamine dose and discussed that relatively small genetic effects are more relevant at lower doses of amphetamine and can be overcome by increasing the amphetamine dose [ 24].
As such, even if the effectiveness of ibuprofen varies over time (e.g. it becomes more or less effective each time it is given), the average treatment effect over all randomisation periods is more relevant than the treatment effect the first time it is given (as would be obtained from a parallel group trial), as this more closely reflects clinical practice.
As the acetaldehyde generation and desorption occur before the acetate condensation, the effect of the acidity is more relevant.
Only a meta-analysis addressing developmental aspects will be able to pinpoint, if the effect of the FTO variants is more relevant for children or for adults.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com