Sentence examples for effect is directly regulated from inspiring English sources
Increasing amounts of Ro52 resulted in a dose-dependent increase in IRF7 ubiquitination (Figure 2B), indicating that this effect is directly regulated by Ro52.
Further studies are required to elucidate the mechanisms by which Myc activation modulates transcript-specific protein translation, and whether these effects are directly regulated by Myc (in a transcription-independent mode) or are secondary to its activation and mediated by Myc-responsive regulators (e.g., RBPs, miRs).
The transfection of Rbpj or together with NICD significantly enhanced luciferase activity, while co-expression of DNMAML efficiently reversed the effects, demonstrating that Mmp2 transcription is directly regulated by Rbpj through the canonical Notch pathway.
First, we analyzed the effects of doxorubicin treatment on the transcription of IκBα, as it is directly regulated by NF-κB.
In addition, Kobayashi et al. demonstrated that, in endothelial cells stimulated with VEGF, LIMK1 activity is directly regulated by its phosphorylation by MK2, and suggested that the VEGF effects were independent of LIMK1 phosphorylation by PAK on Thr508 [41].
Moreover, CXCL5 is directly regulated by TNFα in both adipose tissue and macrophages by NFκB activation, suggesting that CXCL5 mediates the effects of TNFα in insulin resistance.
The gene regulated by SOX2 could be directly regulated or indirectly regulated.
By comparing the response profile of genes that were significantly altered in the hyper, hypo and hypo+ groups, we identified a subset of genes that are most likely to be directly regulated by TH rather than by downstream effects.
