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– Time to effect : interval from onset of cryoablation application to AVB occurrence.
The only exception was Cmax, for which the upper limit of the 90% CI (point estimate 1.2255 with a 90% CI: 0.9983, 1.5045) extended slightly above the pre-defined no relevant effect interval.
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Considering the long exposure-to-effect interval, in- and out migrations may have occurred, inducing a potential non-differential misclassification.
An interaction of imatinib with simvastatin was assumed, if these confidence intervals were not included in the 'no-effect' interval (0.80, 1.25).
The area under the curve (AUC) and maximum concentration (Cmax) ratios for detemir with concurrent liraglutide vs detemir alone met the predefined no-effect interval of 0.80 1.25 (1.03 [90% CI 0.97 1.09] and 1.05 [0.98–1.13], respectively).
We utilised τ to calculate a 95% population effects interval (PEI) within which 95% of the populations' true values are estimated to lie (i.e., mean prevalence±1.96* τ) (Mosteller and Colditz, 1996; Ludema et al, 2011).
However, this differential effect of interval may still be because of chance (interval tamoxifen interaction: P=0.091 in exact logistic regression).
We then tested for the effect of interval length, by computing a power spectrum of interval lengths.
The Slow Wave did not show any effect of interval, but was more positive to targets than nontargets when interval was collapsed.
The present study adds still another example : Accretion of intervals before the tempo-change yields a stronger multiple-look effect than interval accretion thereafter.
The effect on interval cancer has been studied less, but several reports have found no effect of FFDM on interval cancer rate [ 6, 10, 11].
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