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Although I am still unsure of my exact career path, as a result of my time in the Donohue lab, I'm particularly interested in how the environment can effect gene expression in the development of human diseases such as cancer.
The hypothesis does have some traction among some endocrinologists as well as some geneticists studying how hormone mediators, like BPA or soy or beer, can effect gene expression -- what's called an epigenetic effect.
In addition, changes in copper levels can effect gene expression and consequently modify specific functions.
Other data supporting the idea of p50 and Bcl-3 working together to effect gene expression changes with unloading is that all of the p50 targets revealed by the microarray data were also Bcl-3 target genes.
However, point mutations are still a possible occurrence that could potentially effect gene expression.
This suggests that some other mechanism, such as post-transcriptional regulation, can effect gene expression.
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Using a Hairy over-expression system, authors find that Hairy effects gene expression in a context dependent manner on a subset of target genes.
The treatment had a rapid effect on gene expression, 339 and 627 genes were differentially expressed at S2 and S3 respectively.
First, we used linear models to deconvolve time-dependent effects on gene expression from effects due to social defeat.
This suggests that the majority of causal sQTLs have a moderate effect on gene expression.
Fraenkel speculated that the changes accumulated without having much of an effect on gene expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com