Exact(8)
These decreases are of sufficient magnitude to effect cardiac function.
Most tricyclics have a sedating effect, cardiac toxicity, and varying degrees of anticholinergic side effects, which some individuals, especially the elderly, have difficulty tolerating.
The present study was designed to investigate ionic mechanisms underlying arrhythmogenic effect (cardiac toxicity) of trichloromethane in isolated rat hearts and ventricular myocytes and HEK 293 cells stably expressing human Nav1.5, HCN2, or hERG channel using conventional electrophysiological approaches.
Possible mechanisms could be a reduction of edema in the heart or electrolyte shifts that effect cardiac function.
Increases in cardiomyocyte calcium levels and cardiomyocyte sensitivity to calcium [ 33] have been demonstrated to effect cardiac performance.
Studies have shown that apoptotic cell death effect cardiac tissue, and in addition, cells that avoid apoptosis participate in the progression of atherosclerosis [ 30, 31].
Similar(52)
Previous studies on pharmacological treatment of HCD have demonstrated beneficial effects when using drugs with the combined effects; cardiac inotropic support and peripheral vasodilation.
We show that wild populations of D. melanogaster indeed carry major-effect cardiac failure-promoting alleles, and that these can be mapped by standard linkage methods.
To address possible mechanism(s) for these beneficial effects, cardiac-specific transgenic mice expressing HSPB8 were generated.
Cleland, J. G. F. et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure.
Another bit of health folklore "everybody knows" that turned out to be unfounded is vitamin E's protective effect against cardiac problems.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com