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First, by coding for specific binding sites, their effect can be restricted to the tissue context expressing the relevant DNA binding molecules (Schon et al. 2009; Wang et al. 2012).
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The multitasking vascular and neuroprotective effects of VEGF show promise for therapeutic use in neurodegenerative disorders such as ALS, PD, AD and, eventually, progressive MS [ 227– 229], when its harmful vascular side effects can be restricted.
In cancer treatment, PCI as a more selective procedure than systemic chemotherapy will have reduced systemic effects and its activity can be restricted to irradiated tissues.
The DH has voiced concern but so far failed to intervene or produce a single national list for England of treatments which can be restricted because agreed evidence shows they have limited effect.
Noisy aircraft can be restricted or even banned.
The descriptors can be restricted to subsets of the molecule.
Public access can be restricted at any time.
This can be restricted further by local ordinance.
The queries can be restricted to species using special qualifiers.
User interactions can be restricted to circumvent undesired modifications.
Protein searches can be restricted to specific criteria.
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